Fatal toxicity of antidepressant drugs in overdose.

Fatal toxicity of antidepressant drugs in overdose.

A fatal toxicity index (deaths per million National Health Service prescriptions) was calculated for antidepressant drugs on sale during the years 1975-84 in England, Wales, and Scotland. The tricyclic drugs introduced before 1970 had a higher index than the mean for all the drugs studied (p less than 0.001). In this group the toxicity of amitriptyline, dibenzepin, desipramine, and dothiepin wa...

Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data.

Several studies over the past 15 years have compared the number of fatal poisonings due to antidepressant drugs in the United Kingdom with drug use statistics to derive a fatal toxicity index: deaths per million prescriptions. 2 Greater than 10-fold differences in the index have been shown between tricyclic antidepressants and even larger differences between some tricyclics and newer antidepres...

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Fatal toxicity associated with antidepressant use in primary care.

BACKGROUND New selective serotonin reuptake inhibitors (SSRIs) are perceived to be much safer in use than older tricyclic antidepressants (TCAs). However, previous assessments of association with fatal toxicity were made too soon after the introduction of the new drugs to permit accurate estimation. AIM To determine the level of association of antidepressant drugs with fatal poisoning in the ...

Fatal serotonin toxicity caused by moclobemide and fluoxetine overdose.

Both moclobemide and fluoxetine are used in the treatment of depression, and have been shown to produce fewer side effects than conventional tricyclic antidepressants. A combination of moclobemide and fluoxetine has been used in refractory depression, however there is potential for severe serotonin toxicity. We describe a lethal case of serotonin toxicity in a 36 year-old woman after she ingest...